Activelle

Contain the active ingredient: Estradiol-hemihydrate 1mg, Norethisterone-acetate 0.5mg

Estradiol-is a naturally occuring form of-oestrogen and-norethisterone is a synthetic form of-progesterone.

Womens'ovaries gradually produce less and less-oestrogen in the period up to the-menopause, and oestrogen-blood levels decline as a result. The declining levels of-oestrogen can cause distressing-symptoms, such as irregular periods, hot-flushes, night-sweats, mood swings and vaginal-dryness or itching.

Oestrogen(in this case in the form of-estradiol) can be given as a supplement to replace the falling levels in the body and help reduce these distressing symptoms of the menopause. This is known as hormone-replacement-therapy (HRT).

What is it used for?

Hormone-replacement therapy to relieve symptoms-of the-menopause.

Second-line option for preventing-osteoporosis in postmenopausal-women who are at high risk of fractures and cannot take other medicines-licensed for preventing-osteoporosis.

In December 2003, a review of the available evidence on the risks and benefits of HRT- by the Medicines and Healthcare-products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT-long-term to prevent-osteoporosis in women aged over 50 years exceed the benefits. As a result, this medicine-should not be used as a first-line option for preventing postmenopausal-osteoporosis in women over 50. However, it may be used as a second-line option for women at high risk of fractures who cannot take other-medicines that are licensed-for preventing-osteoporosis.

Women considered to be at high risk of developing-fractures following the-menopause include those who have had an early-menopause, those with a family history of-osteoporosis, those who have had recent prolonged-corticosteroid therapy (eg prednisolone), those with a small thin frame, and smokers.

Size : 28 tablets / box